• 首页 >  人工智能 >  智联网
  • 汉赞迪&比邻星创投:2023智能技术在合成生物学中的应用白皮书(47页).pdf

    定制报告-个性化定制-按需专项定制研究报告

    行业报告、薪酬报告

    联系:400-6363-638

  • 《汉赞迪&比邻星创投:2023智能技术在合成生物学中的应用白皮书(47页).pdf》由会员分享,可在线阅读,更多相关《汉赞迪&比邻星创投:2023智能技术在合成生物学中的应用白皮书(47页).pdf(47页珍藏版)》请在本站上搜索。 1、?割?研 BCC?research?研?2021?95?2026?332?2021-2026?撑?(CAGR)?28.4%?筛?封?覆?割?撑练?割?务?模?-?-?-?DBTL?封?的?封?2?1?展?.?3 1.1?.3 1.1.1?.3 1.1.2 DBTL?.4 1.1.3?.5 1.1.4?.8 1.2?.9 1.2.1 筛?.9 1.2.2?.10 1.3?.13 1.4?Ginkgo?Bioworks?.15 2?展?.?18 2.1?-?DBTL?.18 2.2?-?.19 2.2.1?.20 2.2.2 SDLs?-?.26 2.3?-?.27 2.3.1?Biofoundr2、y?TALENs.29 2.3.2?BioAutomata.31 2.4?-?.33 2.4.1?.34 2.4.2?.35 2.4.3?.37 2.4.4 iBioFoundry?务?.38 3?展?.?40 3.1?.40 3.2 SDLs?-?.41 3.3?SDLs?.43 4?.?44?3?1?展?1.1?1.1.1?Synthetic?Biology?去?封?导?去?勃?DNA?封?1953?2003?研?National?Institutes?of?Health,?NIH?National?Genome?Research?Institute?覆?撑?撑练?DNA?封?确?20?23、1?告?去?4?1.1.2 DBTL?撑练?撑练?-?-?-?DBTL?DBTL?撑?1.?-?-?-?覆?1.?Design?DBTL?去?务?DNA?务?去?2.?Build?DNA?DNA?封?务?割?的?割?研 DNA?DNA?封?BioBrick?BglBricks?In-Fusion?Gateway?Golden?Gate?Start-Stop?DNA?(Oligonucleotides?linkers?mediated?DNA?assembly?OLMA)?去?(Zinc?finger?nucleases?ZFN)?去?TALEN?封?去 CRISPR-Cas?CRISPR-Ca4、s?5?CRISPR-Cas9?CRISPR-Cas12a?(Cpf1)?务?割?务?3.?Test?盟?RBS?去?去?封?DBTL?DBTL?研?25?务?(?)?300?600?/d?撑练?100?/d?90%?4.?Learning?DBTL 务?-RNA-?-去?-?割?-?去?覆?研?研?研?告?研?研?去?研?研?DBTL?割?1.1.3?够?/?/?6?导?撑练?去?DBTL?DNA?DNA?DNA?去?1.DNA?DNA?封?1)?务?2)?3)?Sanger?去?DNA?去?2.DNA?DNA?研?21?DNA?封?2.?DNA?务?DNA?DNA?DNA?3.?3?ZFN5、?7?TALEN?CRISPR/Cas?DNA?去?去 CRISPR/Cas9?1)?2)?ZFN?TALEN?3)CRISPR/Cas9?ZFN?TALEN?CRISPR-Cas?Cas?CRISPR?务?CRISPR-Cas?3.?CRISPR?封?Strategies?to?overcome?the?main?challenges?of?the?use?of?CRISPR/Cas9?as?a?replacement?for?cancer?therapy?4.DNA?DNA?DNA?DNA?DNA?DNA?DNA?ligase?chain?reaction,?LCR?polymerase?6、cycling?assembly,?PCA?群?DNA?务?DNA?封?8?1.1.4?告?封?1910?Stephane?Leduc?synthetic?biology?告?2000?封?Nature?去?封?割?DNA?去?封?封?割?10?10?2003?去?务?去?务?2004?-?2007?的?告?2008?-?2013?去?Amyris?2014?-?-?-?研?4.?封?去?9?务?告封?封?封?割?研?资?割?封?1.2?1.2.1 筛?裂?封?筛?封?务?/?封?筛?封?筛?筛?封?务?封?封?够?筛?封?封?筛?2012?2016?封?够?封?封?2019?3?封?去?去?7、封?筛?L-?6-APA?筛?973?863?封?够?2022?5?封?封?封?够?封?封?筛?封?10?5.?封?1.2.2?2021?Zymergen?Ginkgo?IPO?尽?2021?研 Synbiobeta?研?2009-2020?尽?215?2021?180?12?80%?6.?2009-2021?Synbiobeta?11?2018?割?的?研?研?2022?割?2022?模?54?2021?2023?模?103?300?模?去?2022?1?模?8.7?B3?2023?2?模?4?B4?尽?B?19?送?封?务?A?A?2?模?务?割?告?尽封?7.?2023?去?2023/78、/11?A?2023/7/06?Pre-A?2023/6/30?2023/6/25?B?2?务?FDCA?CellX?2023/6/16?A+?12?2023/6/06?A+?-?2023/5/30?+?-?2023/4/26?A+?2023/4/25?Pre-A?2023/4/20?B1?Green?Future?研?2023/3/21?Pre-A?2023/3/21?A?-?2023/3/18?Pre-A?2023/3/8?+?-?2023/2/20?B?AI?2023/02/14?B4?4?务?务?-?务?2023/02/02?A+?3.95?务?PHA?务?56?2023/01/16?9、Pre-A?-?13?1.3?尽?DNA&RNA?务?尽?封?尽?尽?尽?尽?封?务?DNA?封?研?务?Twist?Biosciences?研?DNA?Desktop?Genetics?CRISPR?务?尽?务?尽?封?尽?封?Ginkgo?Bioworks?MetaMixis?尽?封?封?尽?尽?尽?尽?割?去?务?1.?Poseida?Therapeutics?Antheia?2.?Lygos?务?Green?Biologics?3.?务?14?LanzaTech?4.?Agrivida?Plant?Sensory?Systems?5.?Modern?Meadow?6.?Ava?Wine10、ry?撑?务?撑?8.?CB?Insights?模?务?去?空?务?研?封?封?去?15?务?确?去?1.4?Ginkgo?Bioworks?Ginkgo?Bioworks?尽?2008?MIT?Tom?Knight?MIT?Jason?Kelly?Reshma?Shetty?Barry?Canton?Austin?Che?4?2021?9?Ginkgo?Bioworks?150?Ginkgo?Bioworks?务?尽?尽?Foundry?去?Codebase?1?研?研?2?Ginkgo?Bioworks?2017?9?Ginkgo?Bioworks?Bayer?尽Joyn?Bio?封?2011、21?4?Ginkgo?Bioworks?Corteva?Agriscience?封?2016?10?Ginkgo?Bioworks?Cargill?ADM?封?2018?11?Ginkgo?Bioworks?尽 Glycosyn?封?HMO?2019?2?Ginkgo?Bioworks?9000?Motif?Food?Works?去?封?割?去?2018?9?Gingko?Bioworks?尽 Cronos?Group?1.22?够?/?16?2019?6?Gingko?Bioworks?Roche?1600?封?2019?6?Ginkgo?Bioworks?Synlogic?8000?封?12、2020?Ginkgo?Bioworks?Concentric?够?COVID-19?2020?10?Ginkgo?Bioworks?4000?Allonnia?封?务?群?9.?Ginkgo?Bioworks?Ginkgo?Bioworks?Ginkgo?Bioworks?2023?2.75?务?1.75?2023?1?Ginkgo?2023?Foundry?100?2023?Q1?13?Ginkgo?1.?研?Foundry?DNA?模?2.?研?研?Ginkgo?去?(Codebase)?研?Codebase?撑?Foundry?去?Codebase?17?Ginkgo?10.?Gink13、go?Bioworks?Foundry?+?Codebase?Ginkgo?Bioworks?18?2?展?2.1?-?DBTL?封?去CRISPR/Cas9?DNA?DNA?种?研?7?去?告?割?DNA?告?DNA?务?割?务?1-100?的?100-10?封?割?割?务?研?封?研?研?去?割?封?研?务?封?告?割?研?割?研?研?研?DBTL?19?研?DNA?研?务?-?-?-?DBTL?1?务?11.?割?-?-?-?(DBTL)?研?够?研务?去?务?UIUC?2.2?-?务?割?去?研务?研?务?研?务?20?2.2.1?Directed?Evolution?DE?务?Mac14、hine?Learning?ML?务?撑练?研?覆?1.?2.?3.?研?4.?研?5.?去?12.?覆?Cell?Systems?A.?确?MLDE?割?21?割?EVmutation?DeepSequence?MSA?研?研?割?ESM?ProtTrans?13.?研?研?匹?Cell?Systems?B.?封?研?撑练?务?去?务?去?22?14.?研?撑练?Cell?Systems?研?研?100?N?N?割?N-?务?封?NLP?Doc2Vec?mLSTM?transformer?务?NLP?研?割?NLP?封?NLP?AlphaFold?23?RoseTTAFold?ESMFold15、?研?N?C.?MLDE?割?20?割?模?确?务?20?告?MLDE?15.?确?/?确?Cell?Systems?24?MLDE?告?研务?D.?务?务割?尺?尺?确?务?告?E.?封?务?模?告导撑?研?撑?务?务?iBioFAB?封?DNA?iBioFAB?BioAutomata?务?25?16.?MLDE?Cell?Systems?17.?务?务?Cell?Systems?SDLs?Self-Driving?Labs?Autonomous?Experimentation?SDLs?务?告?26?2.2.2 SDLs?-?SDLs?研?研?18.?SDLs?ScienceDirect?16、务?SDLs?DNA?去?去?务?去?AI?空?空?研?割?去?AI?空?务?SDLs?Self-driving?labs?务?模?够?研?割?告?模?封?模?SDLs?-?-?-?27?19.?SDLs?ScienceDirect?SDLs?3?务?0?研?1?撑?2?研?3?-?-?-?SDLs?研?4?研?Adam?Eve?够?SDLs?5?SDLs?2.3?-?务?务?PCR?28?务?匹?匹?BioFoundry?筛?3?务?筛?6?务?资?千?务?务?封?Amyris?尽?Ginkgo?Bioworks?尽?Zymergen?尽?Transcriptic?尽?割?务?-?-?-?217、0.?务?够?DARPA?Living?Foundries?够?够?2011?5?29?4?封?1?1?DNA?DNA?10?20?1/4?7.5?够?告?确?去?2.3.1?Biofoundry?TALENs?TALENs?TALENs?DNA?TALENs?千?告?割?TALENs?Huimin?Zhao?P2A?TALENs?封?务?TALENs?96.2%?TALENs?TALENs?务?TALENs?Huimin?Zhao?模?TALENs?TALENs?Huimin?Zhao?iBioFAB?模?iBioFAB?20?割?DNA?21?a?b?封?21?c?30?21.?iBioF18、AB?a.?b.?iBioFAB?iBioFAB?5?务?c.?iBioFAB?GUI 务?封?iScheduler?GUI?割?ACS?Synthetic?Biology?iBioFAB?DNA?务?Golden?Gate?DNA?Huimin?Zhao?封?Script?Generator?DNA?DNA?iBioFAB?撑练?iBioFAB?iBioFAB?TALENs?iBioFAB?尺?DBTL?务?尺?46?iBioFAB?务?Golden?Gate?撑务?尺?确?务?割?31?确?务?确?务?尺?务?2.3.2?BioAutomata?BioAutomata?模?DBTL?割?119、%?77%?务?尺?iBioFAB?BioAutomata?撑练?割?DBTL?去?iBioFAB?BioAutomata?研?去?BioAutomata?研?BioAutomata?撑练?/?-?GC-MS?-?LC-MS?告?撑练?尺?iBioFAB?研?模?32?22.?务?BioAutomata?研?务?研?研?Nature?Communications?A.?BioAutomata?研?研?BioAutomata?iBioFAB?研?研?研?B.?研?尺?尺?封 33?尺?研?务?务?割?务?模?C.?尺?GP?尺?割?尺?告?96?D.?割?务?导?导?务务?务?撑练?割?务?-?20、务?务?研?务?割?撑练?割?DNA?割?封?封?2.4?-?务?务?务?去?务?34?iBioFoundry?BT+IT?+?iBioFoundry?DNA?研割?务?匹?务?务?务?DNA?HEPA?割?iBioFoundry?1.?2.?3.?务?4.?务?5.?务?6.?研?模?7.?模?撑?8.?2.4.1?DNA?的?导?务?F7?模?PCR?F7?35?PCR?去?割?模?0.5ml?-80C?Arktic?SPT?labtech?F7?模?iBioFoundry?iBioFoundry?iBioFoundry?2.4.2?9?PCR 导?PCR?DNA?1.?去?模?PCR?221、.?PCR?3.?PCR?36?23.?Synthetic?Biology?Journal?24.?Synthetic?Biology?Journal?37?25.?Synthetic?Biology?Journal?2.4.3?务?研?撑?iBioFoundry?模?38?PCR?研 OD?研?OD?研?撑?研?研?务?务?研?务?研?1.?研?OD?研?2.?研?研?撑?3.?研?研?26.?Synthetic?Biology?Journal?2.4.4 iBioFoundry?1.?iBioFoundry 务?割?务?39?iBioFoundry?DNA?2.?iBioFoundry?务22、?务?iBioFoundry?务?3.?务?iBioFoundry 务?务?40?3?展?-?-?-?封?封?告?务?割?20?割?封?务?割模?去?割?务?封?历?撑练?割?2018?6?15?去?去?封?1.?2.模?撑?3.?的?务?4.?够?封?封?3.1?去?匹?撑练?41?研割?,?封?务?去?研?研?3.2 SDLs?-?SDLs?覆?1.?TRY?Titer?Rate?Yield?务?TRY?去?确?-?-?告?务?2.?去?3.?4.?告?务?5.确?/?导?确?务?SDLs?割?SDL?撑练?SDLs?SDLs?SDLs?SDLs?研?务?SDLs?42?封?撑?匹?研?覆23、?SDLs?27.?SDLs?SDLs?务?SDLs?务?SDLs?SDLs?够?确?SDL1?SDL2?SDLs?务?研?封?撑练?ScienceDirect?43?3.3?SDLs?模?SDLs?覆?研?封?SDLs?务?告?SDLs?诱务?封?导?DNA?去?导?务?研?44?4?,?,?,?,?&?.?(2023).?.?,?39(2),?11.?,?,?,?,?,?&?.?(2021).?.?,?37(3),?37.?.?(2018).?:?.?,33(11),?1135-1149.?.?(2022).?:?.?,?38(11),?11.?,?,?,?,?,?&?.?(2021).?24、.?,?2(6),?13.?,?.?(2023).?.?.?(2022).?.?,?,?,?,?.?(2022).?.?,?,?,?,?.?(2022).?.?2022?-?-?4Q?2021?Synthetic?Biology?Venture?Investment?Report?Synbiobeta?,?,?&?.?ibiofoundry?.?,?1-14.?Jinming,?C.?,?Bingzhao,?Z.?,?Yingfei,?M.?A.?,?Xiongfei,?F.?U.?,?Meng,?W.?,?&?Chenli,?L.?.?(2018).?Engineering?platform25、s?for?synthetic?biology?research.?(11).?Yu,?T.,?Boob,?A.?G.,?Singh,?N.,?Su,?Y.,?&?Zhao,?H.?(2023).?In?vitro?continuous?protein?evolution?empowered?by?machine?learning?and?automation.?Cell?systems,?S2405-4712(23)00115-1.?Advance?online?publication.?Martin,?H.?G.,?Radivojevic,?T.,?Zucker,?J.,?Bouchard26、,?K.,?Sustarich,?J.,?Peisert,?S.,?Arnold,?D.,?Hillson,?N.,?Babnigg,?G.,?Marti,?J.?M.,?Mungall,?C.?J.,?Beckham,?G.?T.,?Waldburger,?L.,?Carothers,?J.,?Sundaram,?S.,?Agarwal,?D.,?Simmons,?B.?A.,?Backman,?T.,?Banerjee,?D.,?Tanjore,?D.,?Singh,?A.?(2023).?Perspectives?for?self-driving?labs?in?synthetic?bi27、ology.?Current?opinion?in?biotechnology,?79,?102881.?Gurdo,?N.,?Volke,?D.?C.,?McCloskey,?D.,?&?Nikel,?P.?I.?(2023).?Automating?the?design-build-test-learn?cycle?towards?next-generation?bacterial?cell?factories.?New?biotechnology,?74,?1?15.?Carbonell,?P.,?Radivojevic,?T.,?&?Garca?Martn,?H.?(2019).?Op28、portunities?at?the?Intersection?of?Synthetic?Biology,?Machine?Learning,?and?Automation.?ACS?synthetic?biology,?8(7),?1474?1477.?HamediRad,?M.,?Chao,?R.,?Weisberg,?S.,?Lian,?J.,?Sinha,?S.,?&?Zhao,?H.?(2019).?Towards?a?fully?automated?algorithm?driven?platform?for?biosystems?design.?Nature?communicati29、ons,?10(1),?5150.?Chao,?R.,?Liang,?J.,?Tasan,?I.,?Si,?T.,?Ju,?L.,?&?Zhao,?H.?(2017).?Fully?Automated?One-Step?Synthesis?of?Single-Transcript?TALEN?Pairs?Using?a?Biological?Foundry.?ACS?synthetic?biology,?6(4),?678?685.?Liu,?L.,?Huang,?Y.,?&?Wang,?H.?H.?(2023).?Fast?and?efficient?template-mediated?sy30、nthesis?of?genetic?variants.?Nature?methods,?20(6),?841?848.?Enghiad,?B.,?Xue,?P.,?Singh,?N.,?Boob,?A.?G.,?Shi,?C.,?Petrov,?V.?A.,?Liu,?R.,?Peri,?S.?S.,?Lane,?S.?T.,?Gaither,?E.?D.,?&?Zhao,?H.?(2022).?PlasmidMaker?is?a?versatile,?automated,?and?high?throughput?end-to-end?platform?for?plasmid?construction.?Nature?communications,?13(1),?2697.?Smanski,?M.?J.,?Mead,?D.,?Gustafsson,?C.,?&?Thomas,?M.?G.?(2017).?Meeting?Report?for?Synthetic?Biology?for?Natural?Products?2017:?The?Interface?of?(Meta)Genomics,?Machine?Learning,?and?Natural?Product?Discovery.?ACS?synthetic?biology,?6(5),?737?743.?

    版权声明:本文内容由互联网用户自发贡献,该文观点仅代表作者本人。本站仅提供信息存储空间服务,不拥有所有权,不承担相关法律责任。如发现本站有涉嫌抄袭侵权/违法违规的内容, 举报,一经查实,本站将立刻删除。如若转载,请注明出处:http://lixiangbaogao.com/__hong_xiang_/8469.html

    加载中~

    相关推荐

    加载中~